I know most people are fond of Paypal and/or Payoneer but who has used Skrill before? I've heard that it used to be called Moneybookers sometime back. I believe that a wide range of payment options would be very beneficial to an online business.
Haven't heard much about Skrill and I guess PayPal remains to be the most popular. @Jeff, is there any reason why it seems popular with the casino sites?